As things stand, Pompey are sitting in sixth place with 65 points, but, in a tightly-packed division, a poor run of results in their final handful of matches could see them surrender their spot to one of the chasing pack over the course of the final six games.
But what are the data experts saying about how the League One table will finish?
We've take a look at the third-tier and every club's predicted position and points totals, according to data experts FiveThirtyEight. This is where Portsmouth and all their divisional rivals are tipped to finish:
1. 24th - Swindon Town
Swindon Town will be relegated in last position with 42 projected points according to the data experts. Photo: Dan Mullan
2. 23rd - Rochdale
Rochdale will be relegated in 23rd position with 43 projected points according to the data experts. Photo: Pete Norton
3. 22nd - Bristol Rovers
Rovers will be relegated in 22nd position with 43 projected points according to the data experts. Photo: Pete Norton
4. 21st - Northampton Town
Northampton Town will be relegated in 21st position with 44 projected points according to the data experts. Photo: Pete Norton